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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SMC4
All Species:
29.09
Human Site:
S435
Identified Species:
40
UniProt:
Q9NTJ3
Number Species:
16
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9NTJ3
NP_001002800.1
1288
147182
S435
F
K
S
I
P
A
K
S
N
N
I
I
N
E
T
Chimpanzee
Pan troglodytes
XP_001157958
1288
147223
S435
F
K
S
I
P
A
K
S
N
N
I
I
N
E
T
Rhesus Macaque
Macaca mulatta
XP_001099428
1287
147121
S434
F
K
S
I
P
A
K
S
N
N
V
I
N
E
T
Dog
Lupus familis
XP_535848
1288
147094
S435
F
K
S
I
P
A
K
S
E
K
I
I
T
E
M
Cat
Felis silvestris
Mouse
Mus musculus
Q8CG47
1286
146876
S433
L
K
S
V
P
A
K
S
K
T
V
I
N
E
T
Rat
Rattus norvegicus
Q9Z1M9
1233
143186
T388
E
A
S
K
R
A
A
T
L
A
Q
E
L
E
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510551
1069
122201
A289
Y
L
S
R
H
N
T
A
V
S
Q
L
N
K
A
Chicken
Gallus gallus
NP_989849
1274
145838
S406
L
K
N
V
P
S
S
S
E
K
N
I
S
D
A
Frog
Xenopus laevis
P50532
1290
146971
S429
L
K
N
V
P
A
N
S
Q
K
I
I
A
E
E
Zebra Danio
Brachydanio rerio
NP_775360
1289
145687
S434
V
R
G
V
P
A
S
S
E
K
I
I
T
E
A
Tiger Blowfish
Takifugu rubipres
NP_001027927
1326
150958
S431
V
R
G
V
P
A
S
S
E
K
A
I
A
D
A
Fruit Fly
Dros. melanogaster
Q9VJE5
1690
189046
T690
S
K
E
Q
A
A
K
T
L
N
D
K
E
Q
L
Honey Bee
Apis mellifera
XP_396862
1282
148175
N371
L
Y
K
V
P
E
K
N
T
K
D
I
Q
E
Y
Nematode Worm
Caenorhab. elegans
Q20060
1549
176553
A441
L
E
A
A
P
E
K
A
E
R
K
I
A
K
C
Sea Urchin
Strong. purpuratus
XP_797583
1289
146235
L435
T
R
E
K
Q
K
K
L
V
K
N
L
Q
K
E
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9FJL0
1241
141112
L384
S
S
N
L
I
P
K
L
Q
E
N
I
P
K
L
Baker's Yeast
Sacchar. cerevisiae
Q12267
1418
162171
A501
T
K
H
S
I
S
E
A
E
N
M
L
E
E
L
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.5
98.3
94
N.A.
89.5
24
N.A.
67.8
75.3
76.9
67.9
66.7
20.1
45.9
29.9
48.1
Protein Similarity:
100
99.6
98.9
96.5
N.A.
94.8
47.5
N.A.
75
86.3
87.5
83.5
81.2
40.2
63.9
47.5
65.4
P-Site Identity:
100
100
93.3
73.3
N.A.
66.6
20
N.A.
13.3
26.6
46.6
40
26.6
26.6
26.6
20
6.6
P-Site Similarity:
100
100
100
73.3
N.A.
80
26.6
N.A.
46.6
60
60
53.3
46.6
40
40
46.6
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
41.3
35.6
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
58.7
55.4
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
13.3
20
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
33.3
53.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
6
6
6
6
59
6
18
0
6
6
0
18
0
24
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
6
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
12
0
0
12
0
% D
% Glu:
6
6
12
0
0
12
6
0
36
6
0
6
12
59
12
% E
% Phe:
24
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
12
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
6
0
6
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
24
12
0
0
0
0
0
30
71
0
0
0
% I
% Lys:
0
53
6
12
0
6
59
0
6
42
6
6
0
24
6
% K
% Leu:
30
6
0
6
0
0
0
12
12
0
0
18
6
0
18
% L
% Met:
0
0
0
0
0
0
0
0
0
0
6
0
0
0
6
% M
% Asn:
0
0
18
0
0
6
6
6
18
30
18
0
30
0
0
% N
% Pro:
0
0
0
0
65
6
0
0
0
0
0
0
6
0
0
% P
% Gln:
0
0
0
6
6
0
0
0
12
0
12
0
12
6
0
% Q
% Arg:
0
18
0
6
6
0
0
0
0
6
0
0
0
0
0
% R
% Ser:
12
6
42
6
0
12
18
53
0
6
0
0
6
0
0
% S
% Thr:
12
0
0
0
0
0
6
12
6
6
0
0
12
0
24
% T
% Val:
12
0
0
36
0
0
0
0
12
0
12
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
6
6
0
0
0
0
0
0
0
0
0
0
0
0
6
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _